PPARgamma-2 and ADRB3 polymorphisms in connective tissue diseases and lipid disorders.

ABSTRACT:

Background

The aim of the research genetic study was to investigate the association between variants (C1431T and Pro12Ala) of the peroxisome proliferator-activated receptor (PPARgamma-2) gene, Trp64Arg polymorphism of the beta-3-adrenergic receptor gene and lipid profile in Polish population including group of 103 patients with connective tissue disease (CTD) and 103 sex-and age-matched controls in context of statin use.

Methods

Anthropometric and biochemical parameters were measured by routine methods, followed by genotyping (TagMan^® Genotyping Assays, PCR-restriction fragment length polymorphism analysis). Nearly 30% of CTD patients used statins and 10% of the control group.

Results

Although there were no differences between alleles and genotypes p

SUBMITTER: Grygiel-Gorniak B 

PROVIDER: S-EPMC5868601 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature