Tooth loss and risk of colorectal cancer: a dose-response meta-analysis of prospective cohort studies.

ABSTRACT:

Background

Previous studies have indicated that tooth loss is associated with colorectal cancer risk but have presented controversial results.

Methods

We conducted a dose-response meta-analysis in order to investigate the correlation between tooth loss and colorectal cancer risk. Up to August 2017, six eligible studies were included in this meta-analysis.

Results

Our results showed statistically significant association between tooth loss and colorectal cancer (OR =1.08, 95% CI: 1.03-1.15, P<0.001). In addition, we obtained the best fit at an inflection point of every two tooth loss in piecewise regression analysis, and the summary relative risk (RR) of colorectal cancer for an increase of every two tooth loss was 1.06 (95% CI: 1.02-1.11, P<0.001). Furthe

SUBMITTER: Ma P 

PROVIDER: S-EPMC5868628 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature