Oxygen dependence of endothelium-dependent vasodilation: importance in chronic obstructive pulmonary disease.

ABSTRACT:

Introduction

Epidemiological studies have shown increased morbidity and mortality in patients with coronary artery disease (CAD) and chronic obstructive pulmonary disease (COPD). We aimed to characterize the oxygen dependence of endothelial function in patients with CAD and coexisting COPD.

Material and methods

In CAD patients with and without COPD (n = 33), we non-invasively measured flow-mediated dilation (FMD) and intima-media thickness (IMT) of the brachial artery (BA), forearm blood flow (FBF), and perfusion of the cutaneous microcirculation with laser Doppler perfusion imaging (LDPI). In an experimental setup, vascular function was assessed in healthy volunteers (n = 5) breathing 12% oxygen or 100% oxygen in comparison to room air.

Results

COPD was

SUBMITTER: Keymel S 

PROVIDER: S-EPMC5868657 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature