Genetic variants in cellular transport do not affect mesalamine response in ulcerative colitis.

ABSTRACT:

Background and aims

Mesalamine is commonly used to treat ulcerative colitis (UC). Although mesalamine acts topically, in vitro data suggest that intracellular transport is required for its beneficial effect. Genetic variants in mucosal transport proteins may affect this uptake, but the clinical relevance of these variants has not been studied. The aim of this study was to determine whether variants in genes involved in cellular transport affect the response to mesalamine in UC.

Methods

Subjects with UC from a 6-week clinical trial using multiple doses of mesalamine were genotyped using a genome-wide array that included common exome variants. Analysis focused on cellular transport gene variants with a minor allele frequency >5%. Mesalamine response was defined as improvement

SUBMITTER: Moran CJ 

PROVIDER: S-EPMC5868763 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature