Suppressed plasmablast responses in febrile infants, including children with Kawasaki disease.

ABSTRACT:

Background

Kawasaki disease (KD), the leading cause of acquired heart disease in children, primarily affects infants and toddlers. Investigations on immune responses during KD are hampered by a limited understanding of normal immune responses in these ages. It's well known that Infants have poorer vaccine responses and difficulty with maintaining prolonged serum immunity, but there are few studies on human infants detailing immune deficiencies. Limited studies propose an inability to maintain life-long bone marrow plasma cells. Plasmablasts are a transitional cell form of B cells that lead to long-term Plasma cells. Plasmablasts levels rise in the peripheral blood after exposure to a foreign antigen. In adult studies, these responses are both temporally and functionally well charac

SUBMITTER: Martin M 

PROVIDER: S-EPMC5868766 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature