Microbiota promote secretory cell determination in the intestinal epithelium by modulating host Notch signaling.

ABSTRACT: Resident microbes promote many aspects of host development, although the mechanisms by which microbiota influence host tissues remain unclear. We showed previously that the microbiota is required for allocation of appropriate numbers of secretory cells in the zebrafish intestinal epithelium. Because Notch signaling is crucial for secretory fate determination, we conducted epistasis experiments to establish whether the microbiota modulates host Notch signaling. We also investigated whether innate immune signaling transduces microbiota cues via the Myd88 adaptor protein. We provide the first evidence that microbiota-induced, Myd88-dependent signaling inhibits host Notch signaling in the intestinal epithelium, thereby promoting secretory cell fate determination. These results connect microbio

SUBMITTER: Troll JV 

PROVIDER: S-EPMC5869004 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature