Lsd1 interacts with cMyb to demethylate repressive histone marks and maintain inner ear progenitor identity.

ABSTRACT: During development, multipotent progenitor cells must maintain their identity while retaining the competence to respond to new signalling cues that drive cell fate decisions. This depends on both DNA-bound transcription factors and surrounding histone modifications. Here, we identify the histone demethylase Lsd1 as a crucial component of the molecular machinery that preserves progenitor identity in the developing ear prior to lineage commitment. Although Lsd1 is mainly associated with repressive complexes, we show that, in ear precursors, it is required to maintain active transcription of otic genes. We reveal a novel interaction between Lsd1 and the transcription factor cMyb, which in turn recruits Lsd1 to the promoters of key ear transcription factors. Here, Lsd1 prevents the accumulatio

SUBMITTER: Ahmed M 

PROVIDER: S-EPMC5869009 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature