Decreased feedback learning in anorexia nervosa persists after weight restoration.

ABSTRACT:

Objective

Anorexia Nervosa (AN) is a serious disorder, with a mortality rate the highest of any psychiatric illness. It is notoriously challenging to treat and mechanisms of illness are not well understood. Reward system abnormalities have been proposed across theoretical models of the persistence of AN. Feedback learning is an important component of how reward systems shape behavior and we hypothesized that individuals with AN would show poorer learning from feedback.

Methods

We administered the acquired equivalence task to measure both learning from incremental feedback and generalization of that learning to novel stimuli. Participants were individuals with AN (n = 36) before and after intensive weight restoration treatment and healthy comparison participants (HC, n = 26)

SUBMITTER: Foerde K 

PROVIDER: S-EPMC5869029 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature