Colonic Mucosal Bacteria Are Associated with Inter-Individual Variability in Serum Carotenoid Concentrations.

ABSTRACT:

Background

Relatively high serum carotenoid levels are associated with reduced risks of chronic diseases, but inter-individual variability in serum carotenoid concentrations is modestly explained by diet. The bacterial community in the colon could contribute to the bioaccessibility of carotenoids by completing digestion of plant cells walls and by modulating intestinal permeability.

Objective

To evaluate whether colonic bacterial composition is associated with serum and colon carotenoid concentrations.

Design

The study was a randomized dietary intervention trial in healthy individuals who were at increased risk of colon cancer. Colon mucosal biopsy samples were obtained before and after 6 months of intervention without prior preparation of the bowels.

Participants/

SUBMITTER: Djuric Z 

PROVIDER: S-EPMC5869089 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature