A prospective study of serum microbial translocation biomarkers and risk of AIDS-related non-Hodgkin lymphoma.

ABSTRACT:

Background

Chronic immune activation is a harbinger of AIDS-associated non-Hodgkin lymphoma (AIDS-NHL), yet the underlying basis is unclear. Microbial translocation, the passage of microbial components from the gastrointestinal tract into the systemic circulation, is a source of systemic immune activation in HIV infection and may be an important contributor to chronic B-cell activation and subsequent AIDS-NHL development.

Method

We measured biomarkers of microbial translocation including bacterial receptors/antibodies, intestinal barrier proteins, and macrophage activation-associated cytokines/chemokines, in serum from 200 HIV-infected men from the Multicenter AIDS Cohort Study prior to their AIDS-NHL diagnosis (mean = 3.9 years; SD = 1.6 years) and 200 controls. Controls we

SUBMITTER: Epeldegui M 

PROVIDER: S-EPMC5869109 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature