Novel mediators of statin effects on plaque in HIV: a proteomics approach.

ABSTRACT:

Objective

HIV patients have increased atherosclerotic coronary vascular disease (ASCVD), thought to be mediated through inflammatory mechanisms. We hypothesized that among asymptomatic HIV-infected patients with subclinical coronary plaque, statin therapy would modulate unique inflammatory and cardiovascular proteins in relation to change in subclinical coronary plaque volume. We tested this hypothesis using a novel proteomics approach.

Design

Forty HIV-infected participants were randomized to atorvastatin (40 mg/day) versus placebo, and underwent computed tomography coronary angiography to quantify plaque volume at baseline and 1 year.

Methods

We used Olink Cardiovascular III and Cardiometabolic panels based on dual antibody epitope recognition with linked DNA amplif

SUBMITTER: deFilippi C 

PROVIDER: S-EPMC5869115 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature