Efferent projections of excitatory and inhibitory preBotzinger Complex neurons.

ABSTRACT: The preBötzinger Complex (preBötC), a compact medullary region essential for generating normal breathing rhythm and pattern, is the kernel of the breathing central pattern generator (CPG). Excitatory preBötC neurons in rats project to major breathing-related brainstem regions. Here, we provide a brainstem connectivity map in mice for both excitatory and inhibitory preBötC neurons. Using a genetic strategy to label preBötC neurons, we confirmed extensive projections of preBötC excitatory neurons within the brainstem breathing CPG including the contralateral preBötC, Bötzinger Complex (BötC), ventral respiratory group, nucleus of the solitary tract, parahypoglossal nucleus, parafacial region (RTN/pFRG or alternatively, pF_L /pF_V ), parabrachial and Kölliker-Füse nuclei,

SUBMITTER: Yang CF 

PROVIDER: S-EPMC5869167 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature