Insulin-like growth factor 1 inversely relates to monocyte/macrophage activation markers in HIV.

ABSTRACT: OBJECTIVE:Monocyte/macrophage activation is increased among people with HIV, and may contribute to the heightened risk of atherosclerosis and neurocognitive dysfunction in this population. Insulin-like growth factor 1 (IGF-1) has been shown to attenuate the innate immune response in animal models of atherosclerosis and inflammatory bowel disease. We investigated, for the first time, relationships of circulating IGF-1 with monocyte/macrophage-specific indices among HIV-infected individuals and uninfected controls. DESIGN:Observational. METHODS:One hundred and thirty-one HIV-infected patients and 65 well matched controls without known cardiac disease or viral hepatitis were recruited previously. IGF-1, expressed as a z-score relative to the age-adjusted and sex-adjusted population mean, was

SUBMITTER: Fourman LT 

PROVIDER: S-EPMC5869172 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature