Brain Aging and APOE ε4 Interact to Reveal Potential Neuronal Compensation in Healthy Older Adults.

ABSTRACT: Compensation implies the recruitment of additional neuronal resources to prevent the detrimental effect of age-related neuronal decline on cognition. Recently suggested statistical models comprise behavioral performance, brain activation, and measures related to aging- or disease-specific pathological burden to characterize compensation. Higher chronological age as well as the APOE ε4 allele are risk factors for Alzheimer's disease. A more biological approach to characterize aging compared with chronological age is the brain age gap estimation (BrainAGE), taking into account structural brain characteristics. We utilized this estimate in an fMRI experiment together with APOE variant as measures related to pathological burden and aimed at identifying compensatory regions during working memor

SUBMITTER: Scheller E 

PROVIDER: S-EPMC5869204 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature