Hypertension Accelerates Alzheimer's Disease-Related Pathologies in Pigs and 3xTg Mice.

ABSTRACT: Epidemiological studies suggest there is an association between midlife hypertension and increased risk of late-life Alzheimer's disease (AD). However, whether hypertension accelerates the onset of AD or is a distinct disease that becomes more prevalent with age (comorbidity) remains unclear. This study aimed to test the possible relationship between hypertension and AD pathogenesis. Two animal models were used in this study. For the first model, 7-month-old Lanyu-miniature-pigs were given the abdominal aortic constriction operation to induce hypertension and their AD-related pathologies were assessed at 1, 2, and 3 months after the operation. The results showed that hypertension was detected since 1 month after the operation in the pigs. Levels of Aβ, amyloid precursor protein, RAGE, phos

SUBMITTER: Shih YH 

PROVIDER: S-EPMC5869211 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature