Accuracy of tumor segmentation from multi-parametric prostate MRI and ¹⁸F-choline PET/CT for focal prostate cancer therapy applications.

ABSTRACT:

Background

The study aims to assess the accuracy of multi-parametric prostate MRI (mpMRI) and ¹⁸F-choline PET/CT in tumor segmentation for clinically significant prostate cancer. ¹⁸F-choline PET/CT and 3 T mpMRI were performed in 10 prospective subjects prior to prostatectomy. All subjects had a single biopsy-confirmed focus of Gleason ≥ 3+4 cancer. Two radiologists (readers 1 and 2) determined tumor boundaries based on in vivo mpMRI sequences, with clinical and pathologic data available. ¹⁸F-choline PET data were co-registered to T2-weighted 3D sequences and a semi-automatic segmentation routine was used to define tumor volumes. Registration of whole-mount surgical pathology to in vivo imaging was conducted utilizing two ex vivo prostate specimen M

SUBMITTER: Piert M 

PROVIDER: S-EPMC5869349 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature