Imaging muscle as a potential biomarker of denervation in motor neuron disease.

ABSTRACT:

Objective

To assess clinical, electrophysiological and whole-body muscle MRI measurements of progression in patients with motor neuron disease (MND), as tools for future clinical trials, and to probe pathophysiological mechanisms in vivo.

Methods

A prospective, longitudinal, observational, clinicoelectrophysiological and radiological cohort study was performed. Twenty-nine patients with MND and 22 age-matched and gender-matched healthy controls were assessed with clinical measures, electrophysiological motor unit number index (MUNIX) and T2-weighted whole-body muscle MRI, at first clinical presentation and 4 months later. Between-group differences and associations were assessed using age-adjusted and gender-adjusted multivariable regression models. Within-subject longitudina

SUBMITTER: Jenkins TM 

PROVIDER: S-EPMC5869448 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature