Genome-wide association and interaction studies of CSF T-tau/Aβ₄₂ ratio in ADNI cohort.

ABSTRACT: The pathogenic relevance in Alzheimer's disease (AD) presents a decrease of cerebrospinal fluid amyloid-ß₄₂ (Aß₄₂) burden and an increase in cerebrospinal fluid total tau (T-tau) levels. In this work, we performed genome-wide association study (GWAS) and genome-wide interaction study of T-tau/Aß₄₂ ratio as an AD imaging quantitative trait on 843 subjects and 563,980 single-nucleotide polymorphisms (SNPs) in ADNI cohort. We aim to identify not only SNPs with significant main effects but also SNPs with interaction effects to help explain "missing heritability". Linear regression method was used to detect SNP-SNP interactions among SNPs with uncorrected p-value ≤0.01 from the GWAS. Age, gender, and diagnosis were considered as covariates in both studies. The G

SUBMITTER: Li J 

PROVIDER: S-EPMC5869719 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature