Distinct adipocyte progenitor cells are associated with regional phenotypes of perivascular aortic fat in mice.

ABSTRACT:

Objective

Perivascular adipose tissue depots around the aorta are regionally distinct and have specific functional properties. Thoracic aorta perivascular adipose tissue (tPVAT) expresses higher levels of thermogenic genes and lower levels of inflammatory genes than abdominal aorta perivascular adipose tissue (aPVAT). It is not known whether this distinction is due to the in-vivo functional environment or to cell-autonomous traits that persist outside the in-vivo setting. In this study, we asked whether the progenitor cells in tPVAT and aPVAT have cell-autonomous traits that lead to formation of regionally distinct PVAT.

Methods

We performed microarray analysis of thoracic and abdominal peri-aortic adipose tissues of C57Bl/6J mice to define gene expression profile of each de

SUBMITTER: Tran KV 

PROVIDER: S-EPMC5869733 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature