Modulation of thalamocortical oscillations by TRIP8b, an auxiliary subunit for HCN channels.

ABSTRACT: Hyperpolarization-activated cyclic nucleotide-gated cation (HCN) channels have important functions in controlling neuronal excitability and generating rhythmic oscillatory activity. The role of tetratricopeptide repeat-containing Rab8b-interacting protein (TRIP8b) in regulation of hyperpolarization-activated inward current, I _h, in the thalamocortical system and its functional relevance for the physiological thalamocortical oscillations were investigated. A significant decrease in I _h current density, in both thalamocortical relay (TC) and cortical pyramidal neurons was found in TRIP8b-deficient mice (TRIP8b^-/-). In addition basal cAMP levels in the brain were found to be decreased while the availability of the fast transient A-type K⁺ current, I

SUBMITTER: Zobeiri M 

PROVIDER: S-EPMC5869905 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature