Circulating osteopontin and its association with liver fat content in non-obese women with polycystic ovary syndrome: a case control study.

ABSTRACT:

Background

Osteopontin (OPN) plays an important role in inflammatory processes and insulin resistance. Polycystic ovary syndrome (PCOS) is a reproductive metabolic disease associated with insulin resistance and metabolic abnormalities, including high levels of liver fat content (LFC). The objective of this study was to explore whether circulating OPN independently contributes to elevated LFC in non-obese PCOS patients.

Methods

This study included 61 non-obese PCOS patients and 56 age-matched healthy women from Shanghai, China. After an overnight fast, all participants underwent anthropometric measurements, oral glucose tolerance tests, lipid profile and sex hormone measurements. Quantitative measurement of LFC by ultrasonography was performed. OPN concentrations were measure

SUBMITTER: Wang Y 

PROVIDER: S-EPMC5870073 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature