Impact of Glucose Loading on Variations in CD4⁺ and CD8⁺ T Cells in Japanese Participants with or without Type 2 Diabetes.

ABSTRACT:

Objective

The aim of this study was to examine the fluctuations in CD4⁺ T cells, CD8⁺ T cells, and natural CD4⁺CD25⁺FoxP3⁺T-regulatory (Treg) cells following an oral glucose tolerance test (OGTT) in participants with and those without type 2 diabetes (T2DM).

Methods

19 Japanese participants with T2DM (DM group) and 21 participants without diabetes (non-DM group) were recruited and underwent a 75-g OGTT. The cell numbers of leukocytes, lymphocytes, and the T cell compartment, such as CD4⁺, CD8⁺, and Treg, were calculated for blood samples obtained after an overnight 12 h fast and during a 75-g OGTT at 60 and 120 min.

Results

Before glucose loading, no differences in the cell numbers of leukocy

SUBMITTER: Miya A 

PROVIDER: S-EPMC5870166 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature