Notos - a galaxy tool to analyze CpN observed expected ratios for inferring DNA methylation types.

ABSTRACT:

Background

DNA methylation patterns store epigenetic information in the vast majority of eukaryotic species. The relatively high costs and technical challenges associated with the detection of DNA methylation however have created a bias in the number of methylation studies towards model organisms. Consequently, it remains challenging to infer kingdom-wide general rules about the functions and evolutionary conservation of DNA methylation. Methylated cytosine is often found in specific CpN dinucleotides, and the frequency distributions of, for instance, CpG observed/expected (CpG o/e) ratios have been used to infer DNA methylation types based on higher mutability of methylated CpG.

Results

Predominantly model-based approaches essentially founded on mixtures of Gaussian distrib

SUBMITTER: Bulla I 

PROVIDER: S-EPMC5870242 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature