Local adaptation in European populations affected the genetics of psychiatric disorders and behavioral traits.

ABSTRACT:

Background

Recent studies have used genome-wide data to investigate evolutionary mechanisms related to behavioral phenotypes, identifying widespread signals of positive selection. Here, we conducted a genome-wide investigation to study whether the molecular mechanisms involved in these traits were affected by local adaptation.

Methods

We performed a polygenic risk score analysis in a sample of 2455 individuals from 23 European populations with respect to variables related to geo-climate diversity, pathogen diversity, and language phonological complexity. The analysis was adjusted for the genetic diversity of European populations to ensure that the differences detected would reflect differences in environmental exposures.

Results

The top finding was related to the asso

SUBMITTER: Polimanti R 

PROVIDER: S-EPMC5870256 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature