Inhibiting YAP expression suppresses pancreatic cancer progression by disrupting tumor-stromal interactions.

ABSTRACT:

Background

Hippo/YAP pathway is known to be important for development, growth and organogenesis, and dysregulation of this pathway leads to tumor progression. We and others find that YAP is up-regulated in pancreatic ductal adenocarcinoma (PDAC) and associated with worse prognosis of patients. Activated pancreatic stellate cells (PSCs) forming the components of microenvironment that enhance pancreatic cancer cells (PCs) invasiveness and malignance. However, the role and mechanism of YAP in PDAC tumor-stromal interaction is largely unknown.

Methods

The expression of YAP in Pancreatic cancer cell lines and PDAC samples was examined by Western blot and IHC. The biological role of YAP on cancer cell proliferation, epithelial-mesenchymal transition (EMT) and invasion were evaluat

SUBMITTER: Jiang Z 

PROVIDER: S-EPMC5870346 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature