Changing phenotype and disease behaviour of chronic pancreatitis in India: evidence for gene-environment interactions.

ABSTRACT:

Background

The idiopathic variety of chronic pancreatitis (CP) in India particularly in Kerala state was earlier called 'tropical pancreatitis' with peculiar features: early age of onset, severe malnutrition, diabetes and poor prognosis. A change in disease phenotype and behaviour has been observed recently.

Objective

To review the changing profile of CP in India and examine its relationship with environmental influences and socio-economic development.

Methods

Relevant studies on CP in India were reviewed along with social and economic parameters in Kerala over the past 4 decades.

Results

There has been a definite change in the phenotype of CP in India with onset in mid twenties, better nutritional status, and a much better prognosis compared with the reports i

SUBMITTER: Garg PK 

PROVIDER: S-EPMC5870434 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature