PH-responsive theranostic nanocomposites as synergistically enhancing positive and negative magnetic resonance imaging contrast agents.

ABSTRACT:

Background

The rational design of theranostic nanoprobe to present responsive effect of therapeutic potency and enhanced diagnostic imaging in tumor milieu plays a vital role for efficient personalized cancer therapy and other biomedical applications. We aimed to afford a potential strategy to pose both T₁- and T₂-weighted MRI functions, and thereby realizing imaging guided drug delivery and targeted therapy.

Results

Theranostic nanocomposites Mn-porphyrin&Fe₃O₄@SiO₂@PAA-cRGD were fabricated and characterized, and the nanocomposites were effectively used in T₁- and T₂-weighted MRI and pH-responsive drug release. Fluorescent imaging also showed that the nanocomposites specifically accumulated in lung

SUBMITTER: Huang X 

PROVIDER: S-EPMC5870481 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature