Systemic evaluation of cellular reprogramming processes exploiting a novel R-tool: eegc.

ABSTRACT:

Motivation

Cells derived by cellular engineering, i.e. differentiation of induced pluripotent stem cells and direct lineage reprogramming, carry a tremendous potential for medical applications and in particular for regenerative therapies. These approaches consist in the definition of lineage-specific experimental protocols that, by manipulation of a limited number of biological cues-niche mimicking factors, (in)activation of transcription factors, to name a few-enforce the final expression of cell-specific (marker) molecules. To date, given the intricate complexity of biological pathways, these approaches still present imperfect reprogramming fidelity, with uncertain consequences on the functional properties of the resulting cells.

Results

We propose a novel tool eegc to eva

SUBMITTER: Zhou X 

PROVIDER: S-EPMC5870561 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature