A multi-scenario genome-wide medical population genetics simulation framework.

ABSTRACT:

Motivation

Recent technological advances in high-throughput sequencing and genotyping have facilitated an improved understanding of genomic structure and disease-associated genetic factors. In this context, simulation models can play a critical role in revealing various evolutionary and demographic effects on genomic variation, enabling researchers to assess existing and design novel analytical approaches. Although various simulation frameworks have been suggested, they do not account for natural selection in admixture processes. Most are tailored to a single chromosome or a genomic region, very few capture large-scale genomic data, and most are not accessible for genomic communities.

Results

Here we develop a multi-scenario genome-wide medical population genetics simulation

SUBMITTER: Mugo JW 

PROVIDER: S-EPMC5870573 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature