BCL-X_L overexpression promotes tumor progression-associated properties.

ABSTRACT: By using human melanoma and glioblastoma cell lines and their derivative BCL-X_L overexpressing clones, we investigated the role of BCL-X_L in aggressive features of these two tumor histotypes. We found that in both models, BCL-X_L overexpression increased in vitro cell migration and invasion and facilitated tumor cells to form de novo vasculogenic structures. Furthermore, BCL-X_L overexpressing cells exhibited higher tumors sphere formation capacity and expressed higher levels of some stem cell markers, supporting the concept that BCL-X_L plays essential roles in the maintenance of cancer stem cell phenotype. BCL-X_L expression reduction by siRNA, the exposure to a BCL-X_L-specific inhibitor and the use of a panel of hu

SUBMITTER: Trisciuoglio D 

PROVIDER: S-EPMC5870591 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature