Bioinformatic analysis of prognostic value of ZW10 interacting protein in lung cancer.

ABSTRACT:

Background

ZWINT is a crucial component of the mitotic checkpoint. However, its possible role in lung cancer is unclear. In this study, we determined its correlation with lung cancer.

Methods

Real-time PCR and immunohistochemistry (IHC) were used to determine 40 collected clinical lung cancer samples. Chi-square test was used to examine possible correlations between ZWINT expression and clinicopathological factors. The prognostic significance of mRNA expression of ZWINT in lung cancer was evaluated using the Kaplan-Meier plotter. Univariate and multivariate Cox proportional hazards regression analysis were performed to determine whether ZWINT is an independent risk factor for overall survival (OS) and disease-free survival (DFS) of lung cancer patients. Additionally, STRING

SUBMITTER: Yuan W 

PROVIDER: S-EPMC5870638 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature