Gracob: a novel graph-based constant-column biclustering method for mining growth phenotype data.

ABSTRACT:

Motivation

Growth phenotype profiling of genome-wide gene-deletion strains over stress conditions can offer a clear picture that the essentiality of genes depends on environmental conditions. Systematically identifying groups of genes from such high-throughput data that share similar patterns of conditional essentiality and dispensability under various environmental conditions can elucidate how genetic interactions of the growth phenotype are regulated in response to the environment.

Results

We first demonstrate that detecting such 'co-fit' gene groups can be cast as a less well-studied problem in biclustering, i.e. constant-column biclustering. Despite significant advances in biclustering techniques, very few were designed for mining in growth phenotype data. Here, we propo

SUBMITTER: Alzahrani M 

PROVIDER: S-EPMC5870648 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature