Phantom: investigating heterogeneous gene sets in time-course data.

ABSTRACT:

Motivation

Gene set analysis is a powerful tool to study the coordinative change of time-course data. However, most existing methods only model the overall change of a gene set, yet completely overlooked heterogeneous time-dependent changes within sub-sets of genes.

Results

We have developed a novel statistical method, Phantom, to investigate gene set heterogeneity. Phantom employs the principle of multi-objective optimization to assess the heterogeneity inside a gene set, which also accounts for the temporal dependency in time-course data. Phantom improves the performance of gene set based methods to detect biological changes across time.

Availability and implementation

Phantom webpage can be accessed at: http://www.baylorhealth.edu/Phantom . R package of Phantom is

SUBMITTER: Gu J 

PROVIDER: S-EPMC5870667 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature