Childhood fish oil supplementation modifies associations between traffic related air pollution and allergic sensitisation.

ABSTRACT:

Background

Studies of potential adverse effects of traffic related air pollution (TRAP) on allergic disease have had mixed findings. Nutritional studies to examine whether fish oil supplementation may protect against development of allergic disease through their anti-inflammatory actions have also had mixed findings. Extremely few studies to date have considered whether air pollution and dietary factors such as fish oil intake may interact, which was the rationale for this study.

Methods

We conducted a secondary analysis of the Childhood Asthma Prevention Study (CAPS) birth cohort, where children were randomised to fish oil supplementation or placebo from early life to age 5 years. We examined interactions between supplementation and TRAP (using weighted road density at plac

SUBMITTER: Hansell AL 

PROVIDER: S-EPMC5870687 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature