MFIB: a repository of protein complexes with mutual folding induced by binding.

ABSTRACT:

Motivation

It is commonplace that intrinsically disordered proteins (IDPs) are involved in crucial interactions in the living cell. However, the study of protein complexes formed exclusively by IDPs is hindered by the lack of data and such analyses remain sporadic. Systematic studies benefited other types of protein-protein interactions paving a way from basic science to therapeutics; yet these efforts require reliable datasets that are currently lacking for synergistically folding complexes of IDPs.

Results

Here we present the Mutual Folding Induced by Binding (MFIB) database, the first systematic collection of complexes formed exclusively by IDPs. MFIB contains an order of magnitude more data than any dataset used in corresponding studies and offers a wide coverage of know

SUBMITTER: Ficho E 

PROVIDER: S-EPMC5870711 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature