The Short-term Impact of Symptom-defined COPD Exacerbation Recovery on Health Status and Lung Function.

ABSTRACT: Background: This study examined the short-term effects of symptom-defined exacerbation recovery on health status and pulmonary function in moderate to severe chronic obstructive pulmonary disease (COPD) patients. Methods: Secondary analyses of pooled data from two 12-week Phase II international, randomized controlled trials using the EXAcerbations of Chronic Pulmonary Disease Tool (EXACT) to identify symptom-defined exacerbations were conducted. Recovery was categorized as recovered, unrecovered (persistent worsening), or censored. Multiple regression analyses were used to test the effect of recovery status on change in the St George's Respiratory Questionnaire (SGRQ) and forced expiratory volume in 1 second (FEV₁) from baseline to Week 12. Eva

SUBMITTER: Murray LT 

PROVIDER: S-EPMC5870737 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature