CloudNeo: a cloud pipeline for identifying patient-specific tumor neoantigens.

ABSTRACT:

Summary

We present CloudNeo, a cloud-based computational workflow for identifying patient-specific tumor neoantigens from next generation sequencing data. Tumor-specific mutant peptides can be detected by the immune system through their interactions with the human leukocyte antigen complex, and neoantigen presence has recently been shown to correlate with anti T-cell immunity and efficacy of checkpoint inhibitor therapy. However computing capabilities to identify neoantigens from genomic sequencing data are a limiting factor for understanding their role. This challenge has grown as cancer datasets become increasingly abundant, making them cumbersome to store and analyze on local servers. Our cloud-based pipeline provides scalable computation capabilities for neoantigen identificati

SUBMITTER: Bais P 

PROVIDER: S-EPMC5870764 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature