Efficient simulation of intrinsic, extrinsic and external noise in biochemical systems.

ABSTRACT:

Motivation

Biological cells operate in a noisy regime influenced by intrinsic, extrinsic and external noise, which leads to large differences of individual cell states. Stochastic effects must be taken into account to characterize biochemical kinetics accurately. Since the exact solution of the chemical master equation, which governs the underlying stochastic process, cannot be derived for most biochemical systems, approximate methods are used to obtain a solution.

Results

In this study, a method to efficiently simulate the various sources of noise simultaneously is proposed and benchmarked on several examples. The method relies on the combination of the sigma point approach to describe extrinsic and external variability and the τ -leaping algorithm to account for the stocha

SUBMITTER: Pischel D 

PROVIDER: S-EPMC5870780 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature