Cognitive Function and White Matter Changes Associated with Renal Transplantation.

ABSTRACT:

Background

End-stage renal disease (ESRD) is a disease with an aging population and a high prevalence of cognitive impairment affecting quality of life, health care costs and mortality. Structural changes in the brain with decreased white matter integrity have been observed in ESRD. Understanding the changes in cognition and associated changes in brain structure after renal transplantation can help define the mechanisms underlying cognitive impairment in ESRD.

Methods

We conducted a prospective, observational cohort study in ESRD patients listed for renal transplantation and followed them post-transplantation. We assessed their cognitive function with a battery of neuropsychological tests and brain white matter integrity with diffusion tensor imaging (DTI) both before transp

SUBMITTER: Gupta A 

PROVIDER: S-EPMC5870800 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature