Modular Self-Assembly of Protein Cage Lattices for Multistep Catalysis.

ABSTRACT: The assembly of individual molecules into hierarchical structures is a promising strategy for developing three-dimensional materials with properties arising from interaction between the individual building blocks. Virus capsids are elegant examples of biomolecular nanostructures, which are themselves hierarchically assembled from a limited number of protein subunits. Here, we demonstrate the bio-inspired modular construction of materials with two levels of hierarchy: the formation of catalytically active individual virus-like particles (VLPs) through directed self-assembly of capsid subunits with enzyme encapsulation, and the assembly of these VLP building blocks into three-dimensional arrays. The structure of the assembled arrays was successfully altered from an amorphous aggregate to an

SUBMITTER: Uchida M 

PROVIDER: S-EPMC5870838 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature