An approach to infer putative disease-specific mechanisms using neighboring gene networks.

ABSTRACT:

Motivation

The ultimate goal of any experiment is to understand the biological phenomena underlying the condition investigated. This process often results in genes network through which a certain biological mechanism is explained. Such networks have been proven to be extremely useful, for the prediction of mechanisms of action of drugs or the responses of an organism to a specific impact (e.g. a disease, a treatment, etc.). Here, we introduce an approach able to build a network that captures the putative mechanisms at play in the given condition, by using datasets from multiple experiments studying the same phenotype. This method takes advantage of known interactions extracted from multiple sources such as protein-protein interactions and curated biological pathways. Based on such

SUBMITTER: Ansari S 

PROVIDER: S-EPMC5870849 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature