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LASER server: ancestry tracing with genotypes or sequence reads.

ABSTRACT:

Summary

To enable direct comparison of ancestry background in different studies, we developed LASER to estimate individual ancestry by placing either sezquenced or genotyped samples in a common ancestry space, regardless of the sequencing strategy or genotyping array used to characterize each sample. Here we describe the LASER server to facilitate application of the method to a wide range of genetic studies. The server provides genetic ancestry estimation for different geographic regions and user-friendly interactive visualization of the results.

Availability and implementation

The LASER server is freely accessible at http://laser.sph.umich.edu/.

Contact

dtaliun@umich.edu or wangcl@gis.a-star.edu.sg.

Supplementary information

Supplementary data are available at Bioinformatics online.

SUBMITTER: Taliun D

PROVIDER: S-EPMC5870850 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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LASER server: ancestry tracing with genotypes or sequence reads.

Taliun Daniel D Chothani Sonia P SP Schönherr Sebastian S Forer Lukas L Boehnke Michael M Abecasis Gonçalo R GR Wang Chaolong C

Bioinformatics (Oxford, England) 20170701 13

<h4>Summary</h4>To enable direct comparison of ancestry background in different studies, we developed LASER to estimate individual ancestry by placing either sezquenced or genotyped samples in a common ancestry space, regardless of the sequencing strategy or genotyping array used to characterize each sample. Here we describe the LASER server to facilitate application of the method to a wide range of genetic studies. The server provides genetic ancestry estimation for different geographic regions ...[more]

PMID: 28200055

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