Computational modeling of in vivo and in vitro protein-DNA interactions by multiple instance learning.

ABSTRACT:

Motivation

The study of transcriptional regulation is still difficult yet fundamental in molecular biology research. While the development of both in vivo and in vitro profiling techniques have significantly enhanced our knowledge of transcription factor (TF)-DNA interactions, computational models of TF-DNA interactions are relatively simple and may not reveal sufficient biological insight. In particular, supervised learning based models for TF-DNA interactions attempt to map sequence-level features ( k -mers) to binding event but usually ignore the location of k -mers, which can cause data fragmentation and consequently inferior model performance.

Results

Here, we propose a novel algorithm based on the so-called multiple-instance learning (MIL) paradigm. MIL breaks each DNA

SUBMITTER: Gao Z 

PROVIDER: S-EPMC5870851 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature