Glucosamine use and risk of colorectal cancer: results from the Cancer Prevention Study II Nutrition Cohort.

ABSTRACT:

Purpose

Use of glucosamine supplements has been associated with reduced risk of colorectal cancer (CRC) in previous studies; however, information on this association remains limited.

Methods

We examined the association between glucosamine use and CRC risk among 113,067 men and women in the Cancer Prevention Study II Nutrition Cohort. Glucosamine use was first reported in 2001 and updated every 2 years thereafter. Participants were followed from 2001 through June of 2011, during which time 1440 cases of CRC occurred.

Results

As has been observed in prior studies, current use of glucosamine, modeled using a time-varying exposure, was associated with lower risk of CRC (HR 0.83; 95% CI 0.71-0.97) compared to never use. However, for reasons that are unclear, this reduction

SUBMITTER: Kantor ED 

PROVIDER: S-EPMC5870876 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature