QRank: a novel quantile regression tool for eQTL discovery.

ABSTRACT:

Motivation

Over the past decade, there has been a remarkable improvement in our understanding of the role of genetic variation in complex human diseases, especially via genome-wide association studies. However, the underlying molecular mechanisms are still poorly characterized, impending the development of therapeutic interventions. Identifying genetic variants that influence the expression level of a gene, i.e. expression quantitative trait loci (eQTLs), can help us understand how genetic variants influence traits at the molecular level. While most eQTL studies focus on identifying mean effects on gene expression using linear regression, evidence suggests that genetic variation can impact the entire distribution of the expression level. Motivated by the potential higher order asso

SUBMITTER: Song X 

PROVIDER: S-EPMC5870877 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature