Relationships between markers of neurologic and endothelial injury during critical illness and long-term cognitive impairment and disability.

ABSTRACT:

Purpose

Neurologic and endothelial injury biomarkers are associated with prolonged delirium during critical illness and may reflect injury pathways that lead to poor long-term outcomes. We hypothesized that blood-brain barrier (BBB), neuronal, and endothelial injury biomarkers measured during critical illness are associated with cognitive impairment and disability after discharge.

Methods

We enrolled adults with respiratory failure and/or shock and measured plasma concentrations of BBB (S100B), neuronal (UCHL1, BDNF), and endothelial (E-selectin, PAI-1) injury markers within 72 h of ICU admission. At 3 and 12 months post-discharge, we assessed participants' global cognition, executive function, and activities of daily living (ADL). We used multivariable regression to determi

SUBMITTER: Hughes CG 

PROVIDER: S-EPMC5870884 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature