Robust analysis of secondary phenotypes in case-control genetic association studies.

ABSTRACT: The case-control study is a common design for assessing the association between genetic exposures and a disease phenotype. Though association with a given (case-control) phenotype is always of primary interest, there is often considerable interest in assessing relationships between genetic exposures and other (secondary) phenotypes. However, the case-control sample represents a biased sample from the general population. As a result, if this sampling framework is not correctly taken into account, analyses estimating the effect of exposures on secondary phenotypes can be biased leading to incorrect inference. In this paper, we address this problem and propose a general approach for estimating and testing the population effect of a genetic variant on a secondary phenotype. Our approach is bas

SUBMITTER: Xing C 

PROVIDER: S-EPMC5870885 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature