Transcriptional signature associated with early rheumatoid arthritis and healthy individuals at high risk to develop the disease.

ABSTRACT:

Background

Little is known regarding the mechanisms underlying the loss of tolerance in the early and preclinical stages of autoimmune diseases. The aim of this work was to identify the transcriptional profile and signaling pathways associated to non-treated early rheumatoid arthritis (RA) and subjects at high risk. Several biomarker candidates for early RA are proposed.

Methods

Whole blood total RNA was obtained from non-treated early RA patients with <1 year of evolution as well as from healthy first-degree relatives of patients with RA (FDR) classified as ACCP+ and ACCP- according to their antibodies serum levels against cyclic citrullinated peptides. Complementary RNA (cRNA) was synthetized and hybridized to high-density microarrays. Data was analyzed in Genespring Softw

SUBMITTER: Macias-Segura N 

PROVIDER: S-EPMC5870959 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature