Sensitivity to isoflurane anesthesia increases in autism spectrum disorder Shank3^+/∆c mutant mouse model.

ABSTRACT: Autism is a heterogeneous developmental disorder characterized by impaired social interaction, impaired communication skills, and restricted and repetitive behavior. The abnormal behaviors of these patients can make their anesthetic and perioperative management difficult. Evidence in the literature suggests that some patients with autism or specific autism spectrum disorders (ASD) exhibit altered responses to pain and to anesthesia or sedation. A genetic mouse model of one particular ASD, Phelan McDermid Syndrome, has been developed that has a Shank3 haplotype truncation (Shank3^+/Δc). These mice exhibit important characteristics of autism that mimic human autistic behavior. Our study demonstrates that a Shank3^+/ΔC mutation in mice is associated with a reduction in bot

SUBMITTER: Li C 

PROVIDER: S-EPMC5871225 | biostudies-literature | 2017 Mar - Apr

REPOSITORIES: biostudies-literature