Predictive Virtual Infection Modeling of Fungal Immune Evasion in Human Whole Blood.

ABSTRACT: Bloodstream infections by the human-pathogenic fungi Candida albicans and Candida glabrata increasingly occur in hospitalized patients and are associated with high mortality rates. The early immune response against these fungi in human blood comprises a concerted action of humoral and cellular components of the innate immune system. Upon entering the blood, the majority of fungal cells will be eliminated by innate immune cells, i.e., neutrophils and monocytes. However, recent studies identified a population of fungal cells that can evade the immune response and thereby may disseminate and cause organ dissemination, which is frequently observed during candidemia. In this study, we investigate the so far unresolved mechanism of fungal immune evasion in human whole blood by testing hypotheses

SUBMITTER: Prauße MTE 

PROVIDER: S-EPMC5871695 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature